To the hotel (from the Massachusetts Turnpike, Route 90)
Exit LEFT at the Cambridge/Allston exit. (50 cent toll) When the off-ramp splits, keep right (going towards Cambridge). At the end of the ramp, you will see 2 sets of stop lights ahead of you. Go straight through both of them. At this point, you will be crossing a bridge going over the river. After the bridge, turn right onto Memorial Drive, which runs along the river. On the left, you will pass a Polaroid building, a "Strawberries", a "Microcenter", and a "Shell" gas station. Keep going straight until you see the Hyatt on your left.
(Hotel not T accessible)
From the hotel to Harvard Sq
Turn right onto Memorial Drive (river now on your left). Take
this road until you reach John F Kennedy St. (This is a lighted intersection.) Turn right here.
This will lead you into Harvard Square, characterized by high
pedestrian traffic. Harvard University will be on the left, surrounded
by brick walls and tall gates.